| Regulating Pair |
| Introduced Variation |
Inhibition (BIX01294 (BIX)) of EHMT2 |
Protein Info
|
| Induced Change |
Glycine concentration: decrease |
Metabo Info
|
| Summary |
Introduced Variation
Induced Change
|
|
|
|
|
|
|
|
| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of glycine concentration after EHMT2 inhibition through GC/MS based metabolomics. |
| Disease Status |
Bone metastasis |
ICD-11: 2E03 |
| Organ/Tissue/Cell Line |
U2OS cells (Human osteosarcoma cells) |
Bone |
| Subcellular Location |
Nucleus (Chromosome) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
|
| Details |
It is reported that inhibition of EHMT2 leads to the decrease of glycine levels compared with control group in U2OS cells. |
|
|
|
|
|
|
|
| References |
| 1 |
The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation. Cell Metab. 2013 Dec 3;18(6):896-907.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.
