| Regulating Pair |
| Introduced Variation |
Inhibition (Nitrobenzylthioinosine (NBMPR)) of SLC29A2 |
Protein Info
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| Induced Change |
Uridine concentration: decrease (FC = 0.15) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of uridine concentration after SLC29A2 inhibition through C14-labeled amino acids kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Xenopus oocytes |
N.A. |
| Subcellular Location |
Membrane (Cell membrane; Basolateral Membrane); Nucleus membrane |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that inhibition of SLC29A2 leads to the decrease of uridine levels compared with control group in xenopus oocytes. |
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| References |
| 1 |
Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta. Biochem J. 1997 Dec 15;328 ( Pt 3)(Pt 3):739-43.
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