Details of Experiment

Regulating Pair
       Introduced Variation Overexpression of PFKFB4 Protein Info
       Induced Change NADP concentration: decrease Metabo Info
       Summary Introduced Variation         Induced Change 
Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment (1) for Validating Pair [1]
       Method Quantifying the change of NADP concentration after PFKFB4 overexpression through kit detection.
       Disease Status Lung cancer ICD-11: 2C25
       Organ/Tissue/Cell Line H460 cells (Human non-small cell lung carcinoma cells) Lung
A549 cells (Human non-small cell lung carcinoma cells) Lung
       Subcellular Location Cytoplasm (Cytosol)
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that overexpression of PFKFB4 leads to the decrease of NADP levels compared with control group in MCF-7 cells.
Details of Experiment (2) for Validating Pair [1]
       Method Quantifying the change of NADP concentration after PFKFB4 overexpression through kit detection.
       Disease Status Colon cancer ICD-11: 2B90
       Organ/Tissue/Cell Line HCT116 cells (Human colon carcinoma cells) Colon
       Subcellular Location Cytoplasm (Cytosol)
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that overexpression of PFKFB4 leads to the decrease of NADP levels compared with control group in MCF-7 cells.
Details of Experiment (3) for Validating Pair [1]
       Method Quantifying the change of NADP concentration after PFKFB4 overexpression through kit detection.
       Disease Status Prostate cancer ICD-11: 2C82
       Organ/Tissue/Cell Line LNCaP cells (L ymph N ode Ca rcinoma of the P rostate cells) Prostate
       Subcellular Location Cytoplasm (Cytosol)
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that overexpression of PFKFB4 leads to the decrease of NADP levels compared with control group in MCF-7 cells.
Details of Experiment (4) for Validating Pair [1]
       Method Quantifying the change of NADP concentration after PFKFB4 overexpression through kit detection.
       Disease Status Breast cancer ICD-11: 2C60
       Organ/Tissue/Cell Line MCF-7 cells (Human breast cancer cells) Breast
       Subcellular Location Cytoplasm (Cytosol)
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that overexpression of PFKFB4 leads to the decrease of NADP levels compared with control group in MCF-7 cells.
References
1 Fructose-2,6-bisphosphate synthesis by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth. Oncotarget. 2014 Aug 30;5(16):6670-86.

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