Details of Experiment

Regulating Pair
       Introduced Variation Knockout of Fh Protein Info
       Induced Change Glycerol concentration: increase Metabo Info
       Summary Introduced Variation         Induced Change 
Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment (1) for Validating Pair [1]
       Method Quantifying the change of glycerol concentration after FLNB knockout through CE-TOFMS (Capillary electrophoresis time-of-flight mass spectrometry) based metabolomics.
       Disease Status Healthy individual
       Organ/Tissue/Cell Line N.A. Kidney
Urine
       Subcellular Location Mitochondrion; Cytoplasm (Cytosol); Nucleus (Chromosome)
       Tested Species   Species: Mus musculus  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
       Details It is reported that knockout of FLNB leads to the increase of glycerol levels compared with control group in renal tubular epithelial cells.
Details of Experiment (2) for Validating Pair [2]
       Method Quantifying the change of glycerol concentration after FLNB knockout through CE-TOFMS (Capillary electrophoresis time-of-flight mass spectrometry) based metabolomics.
       Disease Status hydronephrosis ICD-11: GB56
       Organ/Tissue/Cell Line Renal tubular epithelial cells Kidney
       Subcellular Location Mitochondrion; Cytoplasm (Cytosol); Nucleus (Chromosome)
       Tested Species   Species: Mus musculus  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
       Details It is reported that knockout of FLNB leads to the increase of glycerol levels compared with control group in renal tubular epithelial cells.
References
1 Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells. Cancer Metab. 2013 Mar 21;1(1):12.
2 A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia. Cell Rep. 2013 May 30;3(5):1440-8.

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