Regulating Pair
       Introduced Variation Overexpression of SLC16A2 Protein Info
       Induced Change Liothyronine concentration: increase Metabo Info
       Summary Introduced Variation         Induced Change 
Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment (1) for Validating Pair [1]
       Method Quantifying the change of liothyronine concentration after SLC16A2 overexpression through kit detection. based metabolomics.
       Disease Status Healthy individual
       Organ/Tissue/Cell Line COS1 cells (Immortalized African monkey kidney cells) Kidney
       Subcellular Location Membrane (Cell membrane)
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that overexpression of SLC16A2 leads to the increase of liothyronine levels compared with control group in JEG3 cells and COS-1 cells.
Details of Experiment (2) for Validating Pair [2]
       Method Quantifying the change of liothyronine concentration after SLC16A2 overexpression through kit detection. based metabolomics.
       Disease Status Hypothyroidism ICD-11: 5A00
       Organ/Tissue/Cell Line JEG3 cells (Human choriocarcinoma cells) Placenta
COS-1 cells (Transformed african green monkey kidney fibroblast cells) Kidney
       Subcellular Location Membrane (Cell membrane)
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that overexpression of SLC16A2 leads to the increase of liothyronine levels compared with control group in JEG3 cells and COS-1 cells.
References
1 Transport of Iodothyronines by Human L-Type Amino Acid Transporters. Endocrinology. 2015 Nov;156(11):4345-55.
2 Mutations in MCT8 in patients with Allan-Herndon-Dudley-syndrome affecting its cellular distribution. Mol Endocrinol. 2013 May;27(5):801-13.

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