| Regulating Pair |
| Introduced Variation |
Glucose decrease (48 hours) |
Metabo Info
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| Induced Change |
PKLR protein expression levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of PKLR protein abundances after glucose decrease through western blot analysis or nanoLC-ESI-Qq-TripleTOF MS/MS analysis. |
| Disease Status |
Hepatocellular carcinoma |
ICD-11: 2C12 |
| Organ/Tissue/Cell Line |
Hep3B cells (Human hepatoma cells) |
Liver |
| Subcellular Location |
Cytoplasm (Cytosol; Extracellular exosome) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that glucose decrease causes the increase of PKLR protein expression compared with control group in the Hep3B cells and Hep3B cells and U937 human monocytic cells. |
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| References |
| 1 |
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell Res. 2015 Apr;25(4):429-44.
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