Details of Experiment

Regulating Pair
Introduced Variation	Methionine decrease (120 hours)	Metabo Info
Induced Change	RAB9A protein expression levels: increase	Protein Info
Summary	Introduced Variation Induced Change

Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair			[1]
Method	Quantifying the variation of RAB9A protein abundances after methionine decrease through 2-DE or silver staining analysis.
Disease Status	Stomach cancer	ICD-11: 2B72
Organ/Tissue/Cell Line	SGC7901 cells (Human gastric carcinoma cells)	Stomach
Subcellular Location	Membrane (Cell membrane); Cytoplasm (Cytoplasmic side; Cytoplasmic vesicle (phagosome membrane; Cytoplasm (Cytoplasmic side); Cytoplasmic vesicle; Phagosome; Cytoplasmic vesicle membrane); Endoplasmic reticulum (Endoplasmic reticulum membrane); Golgi apparatus (Golgi apparatus membrane); Endosome (Late endosome)
Tested Species	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Details	It is reported that methionine decrease causes the increase of RAB9A protein expression compared with control group in the SGC7901 cells.

References
1	Applying proteomic methodologies to analyze the effect of methionine restriction on proliferation of human gastric cancer SGC7901 cells. Clin Chim Acta. 2007 Feb;377(1-2):206-12.

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