| Regulating Pair |
| Introduced Variation |
Gamma-Aminobutyric acid addition (0.5h) |
Metabo Info
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| Induced Change |
GABBR1 protein activity levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of GABBR1 protein activity abundances after GABA addition through FLIPR analysis. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
CHO cells (Chinese hamster ovary cells) |
Ovary |
| Subcellular Location |
Membrane (Cell membrane); Cell junction (Synapse; Postsynaptic cell membrane); Cell projection (Dendrite) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that gamma-aminobutyric acid addition causes the increase of GABBR1 protein activity compared with control group in the Pan-T. |
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| References |
| 1 |
The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000 Nov;131(6):1050-4.
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