| Regulating Pair |
| Introduced Variation |
Tyrosine decrease (12 hours) |
Metabo Info
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| Induced Change |
GPR143 protein expression levels: increase (FC = 5) |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of GPR143 protein abundances after tyrosine decrease through western blot analysis, quantification densitometry analysis. |
| Disease Status |
Albinism |
ICD-11: EC23 |
| Organ/Tissue/Cell Line |
RPE cells (Human retinal pigment epithelial cells) |
Retina |
| Subcellular Location |
Melanosome (Melanosome membrane); Lysosome (Lysosome membrane); Membrane (Apical cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that tyrosine decrease causes the increase of GPR143 protein expression compared with control group in the RPE cells. |
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| References |
| 1 |
L-DOPA is an endogenous ligand for OA1. PLoS Biol. 2008 Sep 30;6(9):e236.
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