Details of Experiment

Regulating Pair
Introduced Variation	Glutamine addition (6 hours)	Metabo Info
Induced Change	HMOX1 protein expression levels: increase	Protein Info
Summary	Introduced Variation Induced Change

Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair			[1]
Method	Quantifying the variation of HMOX1 protein abundances after glutamine addition through immunohistochemistry analysis.
Disease Status	Inflammatory bowel disease	ICD-11: DD72
Organ/Tissue/Cell Line	IECs (Intestinal epithelial cells)	Intestinal epithelium
Subcellular Location	Microsome; Endoplasmic reticulum (Endoplasmic reticulum membrane); Cytoplasm (Cytoplasmic side)
Tested Species	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Details	It is reported that glutamine addition causes the increase of HMOX1 protein expression compared with control group in the intestinal Epithelial cells.

References
1	Acute enteral glutamine infusion enhances heme oxygenase-1 expression in human duodenal mucosa. J Nutr. 2002 Sep;132(9):2570-3.

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