| Regulating Pair |
| Introduced Variation |
Leucine addition (504 hours) |
Metabo Info
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| Induced Change |
NPY mRNA levels: decrease |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of NPY mRNA levels abundances after leucine addition through real-time polymerase chain reaction analysis. |
| Disease Status |
Stomach cancer |
ICD-11: 2B72 |
| Organ/Tissue/Cell Line |
N.A. |
Hypothalamus |
| Subcellular Location |
Secreted; Cytoplasm (Cytoplasmic vesicle; Secretory vesicle; Neuronal dense core vesicle) |
| Tested Species |
Species: Rattus norvegicus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
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| Details |
It is reported that leucine addition causes the decrease of NPY mRNA levels compared with control group in the wistar rats hypothalamus hypothalamus. |
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| References |
| 1 |
Dietary l-leucine supplementation of lactating rats results in a tendency to increase lean/fat ratio associated to lower orexigenic neuropeptide expression in hypothalamus. Peptides. 2010 Jul;31(7):1361-7.
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