| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of ABCA1 mRNA levels abundances after cholesterol addition through quantitative real-time RT-PCR analysis. |
| Disease Status |
Lipid metabolism disorders |
ICD-11: 5C52 |
| Organ/Tissue/Cell Line |
Human skin fibroblasts |
Skin |
| CTX fibroblasts (Cerebrotendineous xanthomatosis patient's fibroblasts) |
Skin |
| CYP27-deficient human fibroblasts |
Skin |
| Subcellular Location |
Membrane (Cell membrane); Endosome |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that cholesterol addition causes the increase of ABCA1 mRNA levels compared with control group in the human skin fibroblasts, CTX fibroblasts and CYP27-deficient human fibroblasts. |
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Induced Change