| Regulating Pair |
| Introduced Variation |
Kynurenic acid addition (18 hours) |
Metabo Info
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| Induced Change |
ADAM17 protein expression levels: decrease |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of ADAM17 protein abundances after kynurenic acid addition through quantikine enzyme-linked immunosorbent assay kits analysis. |
| Disease Status |
Inflammatory bowel disease |
ICD-11: DD72 |
| Organ/Tissue/Cell Line |
PBMCs (Human peripheral blood mononuclear cells) |
Peripheral blood |
| Monocytes |
Peripheral blood |
| Subcellular Location |
Membrane |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that kynurenic acid addition causes the decrease of ADAM17 protein expression compared with control group in the human peripheral blood mononuclear cells and monocytes. |
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| References |
| 1 |
Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006 Aug 4;281(31):22021-22028.
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