| Regulating Pair |
| Introduced Variation |
Epipregnanolone sulphate addition (0.25 hour) |
Metabo Info
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| Induced Change |
TRPM3 protein activity levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of TRPM3 protein activity abundances after epipregnanolone sulphate addition through wholecell voltageclamp or Ca2+ measurement analysis. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
HEK 293 cells (Human embryonic kidney cells) |
Kidney |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that epipregnanolone sulphate addition causes the increase of TRPM3 protein activity compared with control group in the HEK293 cells. |
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| References |
| 1 |
Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels. Br J Pharmacol. 2010 Sep;161(2):430-41.
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