Details of Metabolite

General Information of MET (ID: META01064)
Name Epipregnanolone sulphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
epipregnanolone sulphate; epipregnanolone sulfate; GTPL4188; Q27077203; [(2S,5S,7R,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-yl]oxidanesulfonic acid; [(3S,5R,10S,13S)-17-acetyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate
Source Endogenous,Human metablite
Structure Type   Arylsulfates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Organic sulfuric acids and derivatives
Arylsulfates
PubChem CID
73755084
Formula
C21H34O5S
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 398.6 Topological Polar Surface Area 89
XlogP 4.5 Complexity 713
Heavy Atom Count 27 Rotatable Bond Count 3
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 5
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      Transient receptor (TRP-CC)
            Long transient receptor potential 4 (TRPM4) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Epipregnanolone sulphate addition (0.25 hour)
                      Induced Change TRPM3 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that epipregnanolone sulphate addition causes the increase of TRPM3 protein activity compared with control group.
References
1 Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels. Br J Pharmacol. 2010 Sep;161(2):430-41.

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