| Regulating Pair |
| Introduced Variation |
Pyruvaldehyde addition (0.5 hour) |
Metabo Info
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| Induced Change |
TRPA1 protein activity levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of TRPA1 protein activity abundances after methylglyoxal addition through western blot analysis. |
| Disease Status |
Intermediate hyperglycaemia |
ICD-11: 5A40 |
| Organ/Tissue/Cell Line |
RINm5F cells (Rat pancreatic beta cells) |
Pancreas islet |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Rattus norvegicus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
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| Details |
It is reported that pyruvaldehyde addition causes the increase of TRPA1 protein activity compared with control group in the RIN cells. |
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| References |
| 1 |
Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells. PLoS One. 2012;7(5):e38005.
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