Details of Metabolite

General Information of MET (ID: META00073)
Name Pyruvaldehyde
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1,2-Propanedione; 1-Ketopropionaldehyde; 2-Keto propionaldehyde; 2-Ketopropionaldehyde; 2-Oxopropanal; 2-Oxopropionaldehyde; 2-oxo-Propionaldehyde; Acetylformaldehyde; Acetylformyl; Aldehyde, pyruvic; CH3COCHO; Ketopropionaldehyde; Methylglyoxal; Oxopropanal; Propanedione; Propanolone; Pyroracemic aldehyde; Pyruvic aldehyde; alpha-Ketopropionaldehyde
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Drug;Food additives;TCM Ingredients;Microbial
Structure Type   Carbonyl compounds  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbonyl compounds
PubChem CID
880
HMDB ID
HMDB0001167
Formula
C3H4O2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00546
DrugBank ID
DB03587
ChEBI ID
17158
FooDB ID
FDB031000
ChemSpider ID
857
METLIN ID
6049
Physicochemical Properties Molecular Weight 72.06 Topological Polar Surface Area 34.1
XlogP -0.4 Complexity 55.9
Heavy Atom Count 5 Rotatable Bond Count 1
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count 2
Function
Pyruvaldehyde is an organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      Transient receptor (TRP-CC)
            Wasabi receptor (TRPA1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Pyruvaldehyde addition (0.5 hour)
                      Induced Change TRPA1 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Intermediate hyperglycaemia [ICD-11: 5A40]
                      Details It is reported that pyruvaldehyde addition causes the increase of TRPA1 protein activity compared with control group.
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of TP53
                      Induced Change Pyruvaldehyde concentration: decrease (Log2 FC=0.9)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of pyruvaldehyde levels compared with control group.
References
1 Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells. PLoS One. 2012;7(5):e38005.
2 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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