| Regulating Pair |
| Introduced Variation |
Tyramine addition (0.33 hours) |
Metabo Info
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| Induced Change |
TAAR1 protein activity levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of TAAR1 protein activity abundances after tyramine addition through measurement of intracellular cAMP analysis or cAMP binding assay analysis. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
COS-7 cells (African green monkey Renal fibroblasts) |
Kidney |
| HEK 293 cells (Human embryonic kidney cells) |
Kidney |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that tyramine addition causes the increase of TAAR1 protein activity compared with control group in the COS-7 cells and HEK 293 cells. |
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| References |
| 1 |
Pharmacologic characterization of the cloned human trace amine-associated receptor1 (TAAR1) and evidence for species differences with the rat TAAR1. J Pharmacol Exp Ther. 2007 Jan;320(1):475-85.
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