Details of Experiment

Regulating Pair
Introduced Variation	UDP glucose addition (2 hours)	Metabo Info
Induced Change	P2RY14 protein activity levels: increase	Protein Info
Summary	Introduced Variation Induced Change

Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair			[1]
Method	Quantifying the variation of P2RY14 protein activity abundances after UDP-glucose addition through cAMP accumulation assay analysis.
Disease Status	Acute lymphoblastic leukemia	ICD-11: 2B33
Organ/Tissue/Cell Line	P2Y14-HEK293 cells (Human embryonic kidney cells expressing hP2Y14-R)	Kidney
	P2Y14-C6 cells (Rat glioma cells expressing hP2Y14-R)	Brain
	P2Y14-CHO cells (Chinese hamster ovary cells expressing hP2Y14-R)	Ovary
Subcellular Location	Membrane (Cell membrane)
Tested Species	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Details	It is reported that UDP glucose addition causes the increase of P2RY14 protein activity compared with control group in the hP2Y14-HEK293 cells, hP2Y14-C6 cells and hP2Y14-CHO cells.

References
1	Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor. Mol Pharmacol. 2009 Dec;76(6):1341-8.

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