| Regulating Pair |
| Introduced Variation |
3-Hydroxyoctanoic acid addition (1 hours) |
Metabo Info
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| Induced Change |
HCAR3 protein activity levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of HCAR3 protein activity abundances after 3-hydroxyoctanoic acid addition through Ca2+ measurement or cAMP accumulation assay analysis. |
| Disease Status |
Diabetic acidosis |
ICD-11: 5A22 |
| Organ/Tissue/Cell Line |
CHO-k1 cells (Chinese hamster ovary cells) |
Ovary |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that 3-hydroxyoctanoic acid addition causes the increase of HCAR3 protein activity compared with control group in the CHO-k1 cells. |
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| References |
| 1 |
Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis. J Biol Chem. 2009 Aug 14;284(33):21928-21933.
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