| Regulating Pair |
| Introduced Variation |
Glutamic acid addition (0.5 hour) |
Metabo Info
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| Induced Change |
GRM1 protein activity levels: decrease |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of GRM1 protein activity abundances after L-glutamic acid addition through intracellular Ca2+ response analysis. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
CHO cells (Chinese hamster ovary cells) |
Ovary |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Rattus norvegicus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
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| Details |
It is reported that glutamic acid addition causes the decrease of GRM1 protein activity compared with control group in the Pan-T. |
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| References |
| 1 |
[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93.
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