| Regulating Pair |
| Introduced Variation |
Cysteine decrease (72 hours) |
Metabo Info
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| Induced Change |
PARP1 protein abundance levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of PARP1 protein abundances after cysteine decrease through western blot analysis. |
| Disease Status |
Ovarian cancer |
ICD-11: 2C73 |
| Organ/Tissue/Cell Line |
KOC-7C cells (ovarian carcinoma cells) |
Ovaries |
| Subcellular Location |
Nucleus (Nucleolus; Chromosome) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that cysteine decrease causes the increase of PARP1 protein abundance compared with control group in the KOC-7C cells. |
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| References |
| 1 |
Cysteine Deprivation Targets Ovarian Clear Cell Carcinoma Via Oxidative Stress and Iron-Sulfur Cluster Biogenesis Deficit. Antioxid Redox Signal. 2020 Dec 10;33(17):1191-1208.
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