| Regulating Pair |
| Introduced Variation |
Arginine decrease (72 hours) |
Metabo Info
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| Induced Change |
MAPK3 protein abundance levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of MAPK3 protein abundances after arginine decrease through western blot analysis. |
| Disease Status |
Leiomyosarcoma |
ICD-11: 2B58 |
| Organ/Tissue/Cell Line |
SkLMS-1 cells (Human vulva leiomyosarcoma cells) |
Vulva |
| Subcellular Location |
Cytoplasm; Nucleus; Membrane (Caveola) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that arginine decrease causes the increase of MAPK3 protein abundance compared with control group in the SkLMS-1 cells. |
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| References |
| 1 |
Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming. Cell Death Dis. 2020 Aug 20;11(8):662.
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