Details of Experiment

Regulating Pair
Introduced Variation	LysoPS(18:0/0:0) addition (0.5 hour)	Metabo Info
Induced Change	MAPK3 protein phosphorylation levels: increase	Protein Info
Summary	Introduced Variation Induced Change

Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair			[1]
Method	Quantifying the variation of MAPK3 protein phosphorylation abundances after lysophosphatidylinositol addition through western blot analysis.
Disease Status	Inflammatory bowel disease	ICD-11: DD72
Organ/Tissue/Cell Line	HEK 293 cells (Human embryonic kidney cells)	Kidney
Subcellular Location	Cytoplasm; Nucleus; Membrane (Caveola)
Tested Species	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Details	It is reported that lysoPS(18:0/0:0) addition causes the increase of MAPK3 protein phosphorylation compared with control group in the HEK293 cells.

References
1	Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006 Aug 4;281(31):22021-22028.

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