| Regulating Pair |
| Introduced Variation |
Arginine decrease (72 hours) |
Metabo Info
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| Induced Change |
CASP3 protein abundance levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of CASP3 protein abundances after arginine decrease through western blot analysis. |
| Disease Status |
Brain cancer |
ICD-11: 2A00 |
| Organ/Tissue/Cell Line |
U251MG cells (Human glioma cells) |
Brain |
| U87MG cells (Human astroblastoma cells) |
Brain |
| Subcellular Location |
Cytoplasm |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that arginine decrease causes the increase of CASP3 protein abundance compared with control group in the U251MG cells and U87MG cells. |
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| References |
| 1 |
Combinatory Treatment of Canavanine and Arginine Deprivation Efficiently Targets Human Glioblastoma Cells via Pleiotropic Mechanisms. Cells. 2020 Sep 30;9(10):2217.
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