Details of Experiment

Regulating Pair
       Introduced Variation Glucose decrease (48 hours) Metabo Info
       Induced Change SHMT1 mRNA levels: increase Protein Info
       Summary Introduced Variation         Induced Change 
Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment (1) for Validating Pair [1]
       Method Quantifying the variation of SHMT1 abundances after through quantitative real-time RT-PCR analysis.
       Disease Status Cervical Cancer ICD-11: 2C77
       Organ/Tissue/Cell Line Hela cells (Human cervix carcinoma cells) Cervix uteri
       Subcellular Location Cytoplasm
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that glucose decrease causes the increase of SHMT1 mRNA levels compared with control group in the Hela cells.
Details of Experiment (2) for Validating Pair [1]
       Method Quantifying the variation of SHMT1 abundances after through quantitative real-time RT-PCR analysis.
       Disease Status Hepatocellular carcinoma ICD-11: 2C12
       Organ/Tissue/Cell Line Hep3B cells (Human hepatoma cells) Liver
SK-HEP-1 cells (Human hepatoma cells) Liver
       Subcellular Location Cytoplasm
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that glucose decrease causes the increase of SHMT1 mRNA levels compared with control group in the Hep3B cells and SK-HEP-1 cells.
References
1 cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell Res. 2015 Apr;25(4):429-44.

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