Details of Experiment

Regulating Pair
       Introduced Variation Glucose decrease (36 hours) Metabo Info
       Induced Change PROK1 protein expression levels: decrease Protein Info
       Summary Introduced Variation         Induced Change 
Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair [1]
       Method Quantifying the variation of PROK1 protein abundances after glucose decrease through human angiogenic factor proteome profiler protein array analysis.
       Disease Status Healthy individual
       Organ/Tissue/Cell Line HUCPVC (human umbilical cord perivascular cells) Umbilical stalk
First Trimester-HUCPVC (First trimester-human umbilical cord perivascular cells) Umbilical stalk
HUCPVC (human umbilical cord perivascular cells) Umbilical stalk
First Trimester-HUCPVC (First trimester-human umbilical cord perivascular cells) Umbilical stalk
       Subcellular Location Secreted
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that glucose decrease causes the decrease of PROK1 protein expression compared with control group in the term-human umbilical cord perivascular cells, first trimester-HUCPVC, HUCPVC and first trimester-HUCPVC.
References
1 Glucose withdrawal induces Endothelin 1 release with significant angiogenic effect from first trimester (FTM), but not term human umbilical cord perivascular cells (HUCPVC). Angiogenesis. 2020 May;23(2):131-144.

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