| Regulating Pair |
| Introduced Variation |
Linoleic acid addition (4 hours) |
Metabo Info
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| Induced Change |
HNF4A protein activity levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of HNF4A protein activity abundances after linoleic acid addition through affinity isolation/mass-spectrometry analysis. |
| Disease Status |
Type 1 diabetes mellitus |
ICD-11: 5A10 |
| Organ/Tissue/Cell Line |
COS-7 cells (African green monkey Renal fibroblasts) |
Ovary |
| Subcellular Location |
Nucleus |
| Tested Species |
Species: Rattus norvegicus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
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| Details |
It is reported that linoleic acid addition causes the increase of HNF4A protein activity compared with control group in the COS-7 cells. |
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| References |
| 1 |
Identification of an endogenous ligand bound to a native orphan nuclear receptor. PLoS One. 2009;4(5):e5609.
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