General Information of MET (ID: META01449)
Name	Pyruvate
Structure Type	Organic acids
Structure
	2D MOL
Regulatory Network

Full List of Protein(s) Regulating This Metabolite
Transferases (EC 2)
Pyruvate kinase M2 (PKM)		Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
Detailed Information	Protein   Info click to show the details of this protein
Regulating Pair	Experim Info click to show the details of experiment for validating this pair					[1]
Introduced Variation	Knockdown (shRNA) of Pkm
Induced Change	Pyruvate concentration: increase
Summary	Introduced Variation         Induced Change
Disease Status	Lung cancer [ICD-11: 2C25]
Details	It is reported that knockdown of Pkm leads to the increase of pyruvate levels compared with control group.

References
1	The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 2008 Mar 13;452(7184):230-3.

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