Details of Metabolite

General Information of MET (ID: META01415)
Name Acetylhydrazine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(N)1-Acetylisoniazid; 1-Acetyl-2-isonicotinoylhydrazine; Acetyl isoniazid; N-Acetyl-n'-isonicotinoylhydrazine; N-Acetylisoniazid; N-Acetylisonicotinylhydrazide; N'-acetylpyridine-4-carbohydrazide; (N)1-Acetylisoniazid monohydrochloride; Acetylisoniazid
Source Aromatic heteromonocyclic compounds
Structure Type   Pyridinecarboxylic acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Pyridines and derivatives
Pyridinecarboxylic acids and derivatives
PubChem CID
71602
HMDB ID
HMDB0041821
Formula
C8H9N3O2
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=71602"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C07585
ChEBI ID
7207
ChemSpider ID
64672
Physicochemical Properties Molecular Weight 179.18 Topological Polar Surface Area 71.1
XlogP -0.4 Complexity 200
Heavy Atom Count 13 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transferases (EC 2)
            Arylamine N-acetyltransferase 1 (NAT1) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Nat1
                      Induced Change Acetylhydrazine concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of NAT leads to the decrease of acetylhydrazine levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Nat1
                      Induced Change Acetylhydrazine concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of NAT leads to the decrease of acetylhydrazine levels compared with control group.
            Arylamine N-acetyltransferase 2 (NAT2) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Nat2
                      Induced Change Acetylhydrazine concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of NAT leads to the decrease of acetylhydrazine levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Nat2
                      Induced Change Acetylhydrazine concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of NAT leads to the decrease of acetylhydrazine levels compared with control group.
References
1 Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver. Biochem Pharmacol. 2017 Dec 1;145:218-225.

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