Details of Metabolite

General Information of MET (ID: META01270)
Name 2-Hydroxy-3-(1H-imidazol-5-yl)propanoic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Imidazole lactic acid; 3-(imidazol-5-yl)lactic acid; 2-hydroxy-3-(1H-imidazol-5-yl)propanoic acid; Imidazole lactate; 2-Hydroxy-3-(1H-imidazol-5-yl)-propanoic acid; ImLA; L-beta-Imidazolelactic acid; SCHEMBL1131474; CHEBI:27487; AKOS032947942; MCULE-9405168040; 2-hydroxy-3-(imidazol-4-yl)propanoic acid; FT-0627736; 2-hydroxy-3-(1H-imidazol-4-yl)propanoic acid; C05568; Q27103160
Structure Type   Imidazoles  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Azoles
Imidazoles
PubChem CID
784
Formula
C6H8N2O3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 156.14 Topological Polar Surface Area 86.2
XlogP -0.7 Complexity 151
Heavy Atom Count 11 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change 2-Hydroxy-3-(1H-imidazol-5-yl)propanoic acid concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of 2-hydroxy-3-(1H-imidazol-5-yl)propanoic acid levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

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