Details of Metabolite

General Information of MET (ID: META01268)
Name Eicosanedioic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Eicosanedioic acid; Icosanedioic acid; 2424-92-2; Eicosanedioicacid; UNII-SOD235TGNZ; 1,18-octadecanedicarboxylic acid; Octadecane-1,18-dicarboxylic acid; MFCD00059627; SOD235TGNZ; 1,20-eicosanedioic acid; Icosanedioic acid #; 1,20-icosanedioic acid; eicosa-1,20-dioic acid; ACMC-1CR4I; Eicosan-1,20-dioic acid; SCHEMBL213967; DTXSID7062407; octadecamethylenedicarboxylic acid; CHEBI:73728; 1,18-octadecane dicarboxylic acid; ZINC5178634; ANW-25371; LMFA01170035; SBB071720; AKOS024462905; MCULE-1513008382; SS-5128; AC-32521; AK161680; SY048222; DB-125813; E0320; FT-0625650; ST45026885; J-015412; Q27144072
Structure Type   Fatty acids and conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acids and conjugates
PubChem CID
74426
Formula
C20H38O4
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 342.5 Topological Polar Surface Area 74.6
XlogP 7.5 Complexity 272
Heavy Atom Count 24 Rotatable Bond Count 19
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change Eicosanedioic acid concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the increase of eicosanedioic acid levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

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