Details of Metabolite

General Information of MET (ID: META01266)
Name 18-Hydroxyeicosapentaenoic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
SCHEMBL136707; 18-hydroxyeicosapentaenoic acid; 18-hydroxyicosa-2,4,6,8,10-pentaenoic acid
Structure Type   Fatty acids and conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acids and conjugates
PubChem CID
73866844
Formula
C20H30O3
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 318.4 Topological Polar Surface Area 57.5
XlogP 5.7 Complexity 428
Heavy Atom Count 23 Rotatable Bond Count 13
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Group 10 secretory phospholipase A2 (PLA2G10) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Pla2g10
                      Induced Change 18-Hydroxyeicosapentaenoic acid concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Inflammatory bowel disease [ICD-11: DD72]
                      Details It is reported that knockout of Pla2g10 leads to the decrease of 18-hydroxyeicosapentaenoic acid levels compared with control group.
References
1 Group X Secreted Phospholipase A2 Releases 3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility. J Biol Chem. 2016 Mar 25;291(13):6895-911.

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