Details of Metabolite

General Information of MET (ID: META01257)
Name Egtazic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
EGTA; 67-42-5; Egtazic acid; Gedta; Ethylenebis(oxyethylenenitrilo)tetraacetic acid; Ebonta; 6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)-; Ethylene glycol bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid; 1,2-Bis[2-[bis(carboxymethyl)amino]ethoxy]ethane; MFCD00004291; Ethylene Glycol Tetraacetic Acid; Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid; H4egta; NSC 615010; DDTA; 3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid; 1,2-Bis(2-dicarboxymethylaminoethoxy)ethane; UNII-526U7A2651; Ethylenedioxybis(ethyleneamino)tetraacetic acid; Glycol ether diamine tetraacetic acid; (Ethylenebis(oxyethylenenitrilo))tetraacetic acid
Structure Type Organic acids
PubChem CID
6175
Formula
C14H24N2O10
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 380.35 Topological Polar Surface Area 174
XlogP -6.2 Complexity 397
Heavy Atom Count 26 Rotatable Bond Count 17
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 12
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transferases (EC 2)
            Succinate-hydroxymethylglutarate CoA-transferase (SUGCT) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Sugct
                      Induced Change Egtazic acid concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Diabetes mellitus [ICD-11: 5A14]
                      Details It is reported that knockout of Sugct leads to the increase of egtazic acid levels compared with control group.
References
1 Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype. Cell Mol Life Sci. 2020 Sep;77(17):3423-3439.

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