Details of Metabolite

General Information of MET (ID: META01250)
Name Salicylate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
salicylate; 2-Hydroxybenzoate; o-Hydroxybenzoate; hydroxybenzoate; 2-Hydroxybenzoic acid ion(1-); 2-hydroxy-benzoate; 63-36-5; Salicylate ion; Salicylate anion; Benzoic acid, 2-hydroxy-, ion(1-); o-Hydroxybenzoate anion; Salicylic acid, ion(1-); NCGC00178624-02; o-Hydrobenzoate; 2-Oxylatobenzoate; 3twp; 2-carboxyphenolate; o-Hydrobenzoic Acid; 2y7k; 2y7p; 2y7w; 3gf2; 2-Hydroxybenzoate (Na+); 2-Hydroxybenzoic acid anion; ACS No 10; BDBM85513; CHEBI:30762; DTXSID70948389; NSC_5900; BBL000698
Source o-Hydroxybenzoic acid esters
Structure Type   Benzoic acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Benzenoids
Benzene and substituted derivatives
Benzoic acids and derivatives
PubChem CID
54675850
Formula
C7H5O3-
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=54675850"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 137.11 Topological Polar Surface Area 60.4
XlogP 2.4 Complexity 133
Heavy Atom Count 10 Rotatable Bond Count 1
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change Salicylate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the increase of salicylate levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

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