Details of Metabolite

General Information of MET (ID: META01233)
Name Estradiol-17beta-glucuronide
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Estradiol-17beta-glucuronide; Glucuronosylestradiol; 17beta-estradiol 17-glucosiduronic acid; 17beta-Estradiol 17-(beta-D-glucuronide); 1806-98-0; CHEBI:791; CHEMBL1697724; Oestradiol-17beta-glucuronide; 17beta-Estradiol 17beta-D-glucuronide; 3-hydroxyestra-1,3,5(10)-trien-17beta-yl beta-D-glucopyranosiduronic acid; 17beta-estradiol-17-(beta-D-glucuronide); Estradiol 17beta-glucuronide; [3H]estradiol-17beta-glucuronide; [3H]-estradiol-17beta-glucuronide; estradiol 17b glucuronide
Source Aromatic heteropolycyclic compounds
Structure Type   Steroidal glycosides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Steroids and steroid derivatives
Steroidal glycosides
PubChem CID
66424
HMDB ID
HMDB0010317
Formula
C24H32O8
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
FooDB ID
FDB027469
ChemSpider ID
59797
Physicochemical Properties Molecular Weight 448.5 Topological Polar Surface Area 137
XlogP 2.7 Complexity 716
Heavy Atom Count 32 Rotatable Bond Count 3
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 8
Function
17-beta-estradiol glucuronide is a natural human metabolite of 17beta-Estradiol generated in the liver by UDP glucuonyltransferase. Glucuronidation is used to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Sodium/anion cotransporter (SAC)
            Sodium-dependent phosphate transport 4 (SLC17A3) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of SLC17A3
                      Induced Change Estradiol-17beta-glucuronide concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC17A3 leads to the increase of estradiol-17beta-glucuronide levels compared with control group.
References
1 Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem. 2010 Nov 5;285(45):35123-32.

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