Details of Metabolite

General Information of MET (ID: META01186)
Name Molybdopterin
Synonyms   Click to Show/Hide Synonyms of This Metabolite
molybdopterin; Pyranopterin; H2Dtpp-mP; UNII-EPP8L4V5E3; EPP8L4V5E3; pyranopterin-dithiolate; PHOSPHONIC ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER; [(5aR,8R,9aR)-2-amino-4-oxo-6,7-disulfanyl-3,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogen phosphate; SCHEMBL94936; CHEBI:44074; C05924; Q619698; 220399-50-8
Structure Type   Molybdopterin dinucleotides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Molybdopterin dinucleotides
PubChem CID
135398581
Formula
C10H14N5O6PS2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 395.4 Topological Polar Surface Area 170
XlogP -2.9 Complexity 733
Heavy Atom Count 24 Rotatable Bond Count 3
Hydrogen Bond Donor Count 8 Hydrogen Bond Acceptor Count 11
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Lyases (EC 4)
            Cyclic pyranopterin monophosphate synthase (MOCS1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Mocs1
                      Induced Change Molybdopterin concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Organic acid disorderss [ICD-11: 5C50]
                      Details It is reported that knockout of Mocs1 leads to the decrease of molybdopterin levels compared with control group.
References
1 The pathogenesis of molybdenum cofactor deficiency, its delay by maternal clearance, and its expression pattern in microarray analysis. Mol Genet Metab. 2005 May;85(1):12-20.

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