Details of Metabolite

General Information of MET (ID: META01177)
Name Phospho-tyrosine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
phospho-tyrosine; SCHEMBL7274; 50471-EP2269989A1; 50471-EP2270014A1; 50471-EP2272972A1; 50471-EP2272973A1; 50471-EP2277872A1; 50471-EP2280012A2; 50471-EP2287155A1; 50471-EP2295406A1; 50471-EP2295550A2; 50471-EP2298770A1; 50471-EP2298772A1; 50471-EP2305682A1; 50471-EP2308839A1; 50471-EP2308879A1; 50471-EP2311809A1; 76179-EP2295550A2; 76179-EP2308960A1
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
11150150
Formula
C9H12NO6P
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=11150150"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 261.17 Topological Polar Surface Area 127
XlogP -0.6 Complexity 309
Heavy Atom Count 17 Rotatable Bond Count 5
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 7
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      GPCR secretin (GPCR-2)
            Glucagon receptor (GCGR) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Gcgr
                      Induced Change Phospho-tyrosine concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Type 2 diabetes mellitus [ICD-11: 5A11]
                      Details It is reported that knockout of GCGR leads to the decrease of phospho-tyrosine levels compared with control group.
References
1 Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes. BMC Genomics. 2011 Jun 1;12:281.

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