| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment (1) for Validating Pair |
[1] |
| Method |
Quantifying the change of 2-hydroxypropanoic acid concentration after slc2a1a mutation (yap -/-) through LC/MSMS;SRM analysis based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Embryos |
| Tested Species |
Species: Danio rerio (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Actinopteri
Order: Cypriniformes
Family: Danionidae
Genus: Danio
Species: Danio rerio
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| Details |
It is reported that decrease of Yap mRNA caused by Yap loss-of-function mutation leads to the decrease of lactic acid levels compared with control group. |
| Details of Experiment (2) for Validating Pair |
[2] |
| Method |
Quantifying the change of phospho-tyrosine concentration after GCGR knockout through LC/MS/MRM based metabolomics. |
| Disease Status |
Type 2 diabetes mellitus |
ICD-11: 5A11 |
| Organ/Tissue/Cell Line |
N.A. |
Plasma |
| Tested Species |
Species: Danio rerio (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Actinopteri
Order: Cypriniformes
Family: Danionidae
Genus: Danio
Species: Danio rerio
|
| Details |
It is reported that knockout of GCGR leads to the decrease of phospho-tyrosine levels compared with control group. |
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Induced Change