Details of Metabolite

General Information of MET (ID: META01172)
Name N-(5-Aminopentyl)-N-hydroxyacetamide
Synonyms   Click to Show/Hide Synonyms of This Metabolite
N-(5-aminopentyl)-N-hydroxyacetamide; Acetamide, N-(5-aminopentyl)-N-hydroxy-; 144108-69-0; N-hydroxy-N-acetyl-cadaverine; CHEMBL346204; SCHEMBL12649156; ZINC27525435; N-(5-Amino-pentyl)-N-hydroxy-acetamide; N-Acetyl-N-(5-aminopentyl)hydroxylamine
Structure Type   Carboximidic acids  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboximidic acids and derivatives
Carboximidic acids
PubChem CID
10374713
Formula
C7H16N2O2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 160.21 Topological Polar Surface Area 66.6
XlogP -0.6 Complexity 117
Heavy Atom Count 11 Rotatable Bond Count 5
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change N-(5-Aminopentyl)-N-hydroxyacetamide concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of N-(5-aminopentyl)-N-hydroxyacetamide levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

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