Details of Metabolite

General Information of MET (ID: META01163)
Name Uridine 5'-O-thiodiphosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
uridine 5'-O-thiodiphosphate; SCHEMBL15270496
Source Endogenous
Structure Type   Thiophosphoric acid esters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Organic thiophosphoric acids and derivatives
Thiophosphoric acid esters
PubChem CID
54430091
Formula
C9H14N2O11P2S
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 420.23 Topological Polar Surface Area 227
XlogP -3 Complexity 681
Heavy Atom Count 25 Rotatable Bond Count 6
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 12
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      GPCR rhodopsin (GPCR-1)
            P2Y purinoceptor 14 (P2RY14) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Uridine 5'-O-thiodiphosphate addition (2 hours)
                      Induced Change P2RY14 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute lymphoblastic leukemia [ICD-11: 2B33]
                      Details It is reported that uridine 5'-O-thiodiphosphate addition causes the increase of P2RY14 protein activity compared with control group.
References
1 Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor. Mol Pharmacol. 2009 Dec;76(6):1341-8.

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