Details of Metabolite

General Information of MET (ID: META01050)
Name Cytidine-5'-diphosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Cytidine 5'-diphosphate; Cytidine diphosphate; cytidine-5'-diphosphate; 63-38-7; Cytidine 5'-(trihydrogen diphosphate); CDP; Cytidine coenzyme; Cytidine 5'-pyrophosphate; 5'-CDP; Cytidine 5'-diphosphoric acid; Cytidine 5'-pyrophosphoric acid; UNII-1ZH821MXU5; cytidine-diphosphate; BRN 0063920; CYTIDINE, 5'-(TRIHYDROGEN PYROPHOSPHATE); Cytidine pyrophosphate; Cytidine 5'-diphosphate disodium; 1ZH821MXU5; CHEMBL425252; CHEBI:17239; 54394-90-0; [(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate; ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate; EINECS 200-557-1; C9H15N3O11P2
Source Endogenous;Food
Structure Type   Pyrimidine ribonucleotides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Pyrimidine nucleotides
Pyrimidine ribonucleotides
PubChem CID
6119
Formula
C9H15N3O11P2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 403.18 Topological Polar Surface Area 222
XlogP -4.5 Complexity 690
Heavy Atom Count 25 Rotatable Bond Count 6
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 11
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      GPCR rhodopsin (GPCR-1)
            P2Y purinoceptor 14 (P2RY14) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Cytidine-5'-diphosphate addition (2 hours)
                      Induced Change P2RY14 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute lymphoblastic leukemia [ICD-11: 2B33]
                      Details It is reported that cytidine-5'-diphosphate addition causes the increase of P2RY14 protein activity compared with control group.
Full List of Protein(s) Regulating This Metabolite
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of TP53
                      Induced Change Cytidine-5'-diphosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of cytidine-5'-diphosphate levels compared with control group.
      Transferases (EC 2)
            Arylamine N-acetyltransferase 1 (NAT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Knockout of NAT1
                      Induced Change Cytidine-5'-diphosphate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Breast cancer [ICD-11: 2C60]
                      Details It is reported that knockout of NAT1 leads to the decrease of cytidine-5'-diphosphate levels compared with control group.
References
1 Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor. Mol Pharmacol. 2009 Dec;76(6):1341-8.
2 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.
3 CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism. Sci Rep. 2020 Jun 17;10(1):9804.

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