Details of Metabolite

General Information of MET (ID: META00977)
Name (2E,4E)-9-Hydroxyoctadeca-2,4-dienoic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
SCHEMBL1171393
Source Endogenous
Structure Type   Fatty acids and conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acids and conjugates
PubChem CID
19900870
Formula
C18H32O3
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=19900870"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 296.4 Topological Polar Surface Area 57.5
XlogP 5.7 Complexity 295
Heavy Atom Count 21 Rotatable Bond Count 14
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      Transferases (EC 2)
            Stress-activated protein kinase JNK1 (JNK1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation (2E,4E)-9-Hydroxyoctadeca-2,4-dienoic acid addition (0.17 hours)
                      Induced Change MAPK8 protein phosphorylation levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Atherosclerosis [ICD-11: BD40]
                      Details It is reported that (2E,4E)-9-hydroxyoctadeca-2,4-dienoic acid addition causes the increase of MAPK8 protein phosphorylation compared with control group.
            Stress-activated protein kinase JNK2 (JNK2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation (2E,4E)-9-Hydroxyoctadeca-2,4-dienoic acid addition (0.17 hours)
                      Induced Change MAPK9 protein phosphorylation levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Atherosclerosis [ICD-11: BD40]
                      Details It is reported that (2E,4E)-9-hydroxyoctadeca-2,4-dienoic acid addition causes the increase of MAPK9 protein phosphorylation compared with control group.
References
1 Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A. J Biol Chem. 2005 Dec 9;280(49):40676-83.

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