Details of Metabolite

General Information of MET (ID: META00960)
Name 2-Arachidonoyl-sn-glycero-3-phosphate(2-)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-arachidonoyl-sn-glycero-3-phosphate(2-); 2-arachidonoyl-LPA; CHEBI:78209; 2-arachidonoyl-sn-glycerol 3-phosphate; Q27147683; 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate; 2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphate(2-); (2R)-3-hydroxy-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propyl phosphate
Source Endogenous;Sterol lipids;Food
Structure Type   Glycerophosphates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Glycerophospholipids
Glycerophosphates
PubChem CID
53481443
Formula
C23H37O7P-2
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 456.5 Topological Polar Surface Area 119
XlogP 4.1 Complexity 594
Heavy Atom Count 31 Rotatable Bond Count 19
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 7
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      GPCR rhodopsin (GPCR-1)
            Kynurenic acid receptor (GPR35) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 2-Arachidonoyl-sn-glycero-3-phosphate(2-) addition (2.7810^-4 hours)
                      Induced Change GPR35 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Stomach cancer [ICD-11: 2B72]
                      Details It is reported that 2-arachidonoyl-sn-glycero-3-phosphate(2-) addition causes the increase of GPR35 protein activity compared with control group.
References
1 GPR35 is a novel lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2010 Apr 30;395(2):232-7.

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