Details of Metabolite

General Information of MET (ID: META00957)
Name 22-Hydroxycholesterol
Synonyms   Click to Show/Hide Synonyms of This Metabolite
22-Hydroxycholesterol; 17711-16-9; cholest-5-en-3beta,22-diol; (3S,8S,9S,10R,13S,14S,17R)-17-[(2S)-3-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; Cholest-5-ene-3beta,22-diol; SCHEMBL103514; CHEMBL3218924; DTXSID30904340; CHEBI:166802; LMST01010054; Cholest-5-ene-3,22-diol, (3beta)-; Q4631298
Source Endogenous;Mouse metablite
Structure Type   Cholestane steroids  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Steroids and steroid derivatives
Cholestane steroids
PubChem CID
107724
Formula
C27H46O2
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=107724"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 402.7 Topological Polar Surface Area 40.5
XlogP 7 Complexity 624
Heavy Atom Count 29 Rotatable Bond Count 5
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      ATP-binding cassette transporter (ABCT)
            ATP-binding cassette A1 (ABCA1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 22-Hydroxycholesterol addition (24 hours)
                      Induced Change ABCA1 mRNA levels: increase (FC = 2.1)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Lipid metabolism disorders [ICD-11: 5C52]
                      Details It is reported that 22-hydroxycholesterol addition causes the increase of ABCA1 mRNA levels compared with control group.
            ATP-binding cassette G1 (ABCG1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 22-Hydroxycholesterol addition (24 hours)
                      Induced Change ABCG1 mRNA levels: increase (FC = 4.5)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Lipid metabolism disorders [ICD-11: 5C52]
                      Details It is reported that 22-hydroxycholesterol addition causes the increase of ABCG1 mRNA levels compared with control group.
      Transcription factor (TF)
            Sterol regulatory element binding protein-1 (SREBF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 22-Hydroxycholesterol addition (24 hours)
                      Induced Change SREBF1 mRNA levels: increase (FC = 2.5)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Lipid metabolism disorders [ICD-11: 5C52]
                      Details It is reported that 22-hydroxycholesterol addition causes the increase of SREBF1 mRNA levels compared with control group.
References
1 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J Biol Chem. 2001 Oct 19;276(42):38378-87.

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