Details of Metabolite

General Information of MET (ID: META00950)
Name Linoleoylcarnitine (C18:2)*
Synonyms   Click to Show/Hide Synonyms of This Metabolite
O-linoleoylcarnitine; linoleylcarnitine; 9cis,12cis-octadecadienoylcarnitine; (9Z,12Z)-octadeca-9,12-dienoylcarnitine; 3-[(9Z,12Z)-octadeca-9,12-dienoyloxy]-4-(trimethylammonio)butanoate; 3-[(9Z,12Z)-octadeca-9,12-dienoyloxy]-4-(trimethylazaniumyl)butanoate; SCHEMBL3006524; CHEBI:73072; CAR(18:3); LMFA07070092
Source Aliphatic acyclic compounds
Structure Type   Fatty acid esters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acid esters
PubChem CID
51000598
HMDB ID
HMDB0240780
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=51000598"></iframe>
3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
73072
Physicochemical Properties Molecular Weight 423.6 Topological Polar Surface Area 66.4
XlogP 7.2 Complexity 500
Heavy Atom Count 30 Rotatable Bond Count 19
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count 4
Function
O-Linoleoylcarnitine is an acylcarnitine. It is an linoleic ester of carnitine. is an linoleic ester of carnitine.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change Linoleoylcarnitine (C18:2)*linoleoylcarnitine (C18: 2) concentration: increase (FC = 1.25)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the increase of linoleoylcarnitine (C18:2)* levels compared with control group.
      Transferases (EC 2)
            Arylamine N-acetyltransferase 1 (NAT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of NAT1
                      Induced Change Linoleoylcarnitine (C18:2)*linoleoylcarnitine (C18: 2) concentration: decrease (FC = 0.05)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Breast cancer [ICD-11: 2C60]
                      Details It is reported that knockout of NAT1 leads to the decrease of linoleoylcarnitine (C18:2)* levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.
2 CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism. Sci Rep. 2020 Jun 17;10(1):9804.

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