General Information of MET (ID: META00949)
Name DL-Acetylcarnitine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3-(Acetyloxy)-4-(trimethylammonio)butanoateAcetyl-DL-carnitineAcetylcarnitineDL-O-Acetylcarnitine3-(Acetyloxy)-4-(trimethylammonio)butanoic acidGenerator(+-)-Acetylcarnitine(-)-Acetylcarnitine(R)-AcetylcarnitineAcetyl-carnitineAcetyl-L-(-)-carnitineAcetyl-L-carnitineALCARL-Carnitine acetyl esterL-O-AcetylcarnitineLevocarnitine acetylNicetileO-Acetyl-L-carnitineO-AcetylcarnitineAcetylcarnitine, (R)-isomerCarnitine, acetylAcetyl L carnitineMedosanSigma-tau brand OF acetyl L-carnitineAcetyl carnitineBranigenglaxo Brand OF acetyl L-carnitineSigma tau brand OF acetyl L carnitineglaxo Brand OF acetyl L carnitine
Source Aliphatic acyclic compounds
Structure Type   Fatty acid esters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acid esters
PubChem CID
16950
HMDB ID
HMDB0240773
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
73024
FooDB ID
FDB021904
Physicochemical Properties Molecular Weight 203.24 Topological Polar Surface Area 66.4
XlogP 0.4 Complexity 214
Heavy Atom Count 14 Rotatable Bond Count 5
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count 4
Function
DL-Acetylcarnitine is an acylcarnitine. The general role of acylcarnitines is to transport acyl-groups (organic acids and fatty acids) from the cytoplasm into the mitochondria so that they can be broken down to produce energy. This process is known as beta-oxidation.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change DL-Acetylcarnitine concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of DL-acetylcarnitine levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.

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