Details of Metabolite

General Information of MET (ID: META00942)
Name Dihydro-kempferol
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Aromadedrin; Aromadendrin; Dihydro-kaempferol; Dihydro-kempferol; Dihydrokaempferol; Dihydrokempferol
Source Aromatic heteropolycyclic compounds
Structure Type   Flavans  (Click to Show/Hide the Complete Structure Type Hierarchy)
Phenylpropanoids and polyketides
Flavonoids
Flavans
PubChem CID
662
HMDB ID
HMDB0125362
Formula
C15H12O6
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
FooDB ID
FDB012431
Physicochemical Properties Molecular Weight 288.25 Topological Polar Surface Area 107
XlogP 1.8 Complexity 392
Heavy Atom Count 21 Rotatable Bond Count 1
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 6
Function
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-1-benzopyran-4-one is a predicted metabolite generated by BioTransformer that is produced by the metabolism of 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4h-chromen-4-one. It is generated by unspecified-gutmicro enzyme via a flavonoid-c-ring-reduction reaction. This flavonoid-c-ring-reduction occurs in human gut microbiota.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of AN2
                      Induced Change Dihydro-kempferol concentration: increase (FC = 65.64)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the increase of dihydro-kempferol levels compared with control group.
References
1 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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