Details of Metabolite

General Information of MET (ID: META00941)
Name Tricin
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3',5'-O-Dimethyltricetin, '5,7-Dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-1-benzopyran-4-one; Tricin', Tricetin 3',5'-di-methyl ether, 5,7,4'-Trihydroxy-3',5'-dimethoxy-flavone, 5,7,4'-Trihydroxy-3',5'-dimethoxyflavone
Source Endogenous;Polyketides;TCM Ingredients
Structure Type   O-methylated flavonoids  (Click to Show/Hide the Complete Structure Type Hierarchy)
Phenylpropanoids and polyketides
Flavonoids
O-methylated flavonoids
PubChem CID
5281702
HMDB ID
HMDB0124861
Formula
C17H14O7
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C10193
ChEBI ID
59979
FooDB ID
FDB002440
Physicochemical Properties Molecular Weight 330.29 Topological Polar Surface Area 105
XlogP 1.7 Complexity 491
Heavy Atom Count 24 Rotatable Bond Count 3
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7
Function
5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4h-chromen-4-one is a predicted metabolite generated by BioTransformer that is produced by the metabolism of 5,7-dihydroxy-2-(3,4,5-trimethoxyphenyl)-4h-chromen-4-one. It is generated by cyp1a2, cyp2c9, cyp2c19, cyp2d6, cyp2e1, and cyp3a4 enzymes via an o-dealkylation reaction. This o-dealkylation occurs in humans.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of AN2
                      Induced Change Tricin concentration: decrease (FC = 0.21)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the decrease of tricin levels compared with control group.
References
1 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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