Details of Metabolite

General Information of MET (ID: META00937)
Name N-Acetylmuramate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-Acetamido-3-O-((S)-1-carboxyethyl)-2-deoxy-D-glucose; 2-Acetamido-4-O-(1-carboxyethyl)-2-deoxyglucose; 2-Acetamido-4-O-(1-carboxyethyl)-2-deoxyglucose, (beta-D)-isomer; 4-O-NAcMur; Acetylmuramic acid; N-Acetyl-D-muramate; N-Acetyl-D-muramoate; N-Acetyl-D-muramoic acid; N-Acetylisomuramic acid; N-Acetylmuramate; N-Acetylmuramic acid
Source Escherichia Coli Metabolite;Microbial
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
5462244
HMDB ID
HMDB0060493
Formula
C11H19NO8
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C02713
ChEBI ID
21615
ChemSpider ID
4575341
Physicochemical Properties Molecular Weight 293.27 Topological Polar Surface Area 146
XlogP -2.1 Complexity 362
Heavy Atom Count 20 Rotatable Bond Count 5
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 8
Function
This compound belongs to the family of N-acyl-alpha-hexosamines. These are carbohydrate derivatives containing a hexose moeity in which the oxygen atom is replaced by an n-acyl group.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Vitamin D receptor (VDR)
            Vitamin D3 receptor (VDR) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of VDR
                      Induced Change N-Acetylmuramate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of VDR leads to the increase of N-acetylmuramate levels compared with control group.
References
1 Vitamin D receptor promotes healthy microbial metabolites and microbiome. Sci Rep. 2020 Apr 30;10(1):7340.

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